One of the skincare treatments currently gaining widespread attention and frequently reviewed on TikTok is PDRN, or Polydeoxyribonucleotide. This skincare formula can be found in toners, serums, and sheet masks, and is claimed to hydrate the skin and deliver a glass-skin effect. Meanwhile, PDRN treatment is also available in injectable form, requiring administration via injection to achieve optimal effects. So, what exactly is this treatment, and are there any side effects? Read on for the full information!

PDRN Meaning

Source: Pinterest

Scientifically, PDRN is a DNA fragment extracted from salmon sperm, which has a structure very similar to human DNA. This similarity allows our bodies to effectively receive and utilize PDRN for cell regeneration, collagen production, and accelerated wound healing. In South Korea, PDRN has long been used in aesthetic medical procedures such as Rejuran Healer, an injectable treatment also known as a skin booster.

However, in 2025, PDRN has begun to expand into the world of topical skincare. Formulations in the form of serums, creams, and sheet masks are increasingly emerging, offering promises of plumper, more hydrated skin with a glass-skin appearance. 

It’s no surprise that this skincare trend has gone viral in the K-beauty world, especially through high-performance products like the Anua PDRN Hyaluronic Acid Serum and Innisfree’s latest retinol ampoule, which combines PDRN with other active ingredients for maximum results. 

Benefits of PDRN Skincare

PDRN offers a wide range of skincare benefits. According to Vogue Singapore, Dr. Stephanie Ho, a consultant dermatologist and founder of Stephanie Ho Dermatology, highlights its key advantages:

• Skin Regeneration: Stimulates cell turnover and repairs skin tissue. It means that PDRN treatment can help improve dark circles, especially those caused by thin skin, loss of elasticity, or poor skin regeneration rather than pigmentation alone.
• Anti-Aging: Boosts collagen production, reduces fine lines, and restores skin elasticity.
• Intensive Hydration: Enhances the skin’s ability to retain moisture while strengthening the skin barrier.
• Anti-Inflammatory Effects: Soothes sensitive or irritated skin.
• Wound Healing: Accelerates recovery after laser treatments, microneedling, and acne scars.
• Overall Rejuvenation: Promotes healthier, more radiant-looking skin.

PDRN Treatment Side Effects Side and Contraindications

Source: Pinterest

Although PDRN offers promising results, it is not without potential risks. Here are some important considerations about PDRN treatment side effects: 

• Seafood Allergies: Since PDRN is derived from salmon DNA, it should be avoided by individuals with fish allergies.
• Pregnancy & Breastfeeding: There is not enough research to confirm its safety for pregnant or breastfeeding women.
• Active Acne: While PDRN is beneficial for acne scars, it should not be applied to skin with active acne or infections.
• Autoimmune Conditions: Consult a doctor before using PDRN if you have an autoimmune disorder.